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. 2015 May 7;6(5):e1755. doi: 10.1038/cddis.2015.95

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Rescue of Mcl-1-deficient follicle loss by concurrent Bax ablation. (a) Histomorphometric analyses of 3-month ovaries in Mcl-1cKO (n=5), Mcl-1^+/+(n=3) and Mcl-1c/BaxDKO (n=3) females. Values represent average follicle number in ovary per genotype±S.E.M. (b) Ovulation rates of Mcl-1cKO (n=20), Mcl-1^+/+(n=12) and Mcl-1c/BaxDKO (n=3) 3-month females. Values represent average number of ovulated oocytes±S.E.M. (c) MII oocytes from Mcl-1cKO (n=6), Mcl-1^+/+(n=10) and Mcl-1c/BaxDKO (n=3) females (n=104, n=180, n=48 oocytes, respectively) cultured for 24 h and values represent the average percentage of fragmented oocytes per female±S.E.M. (d) Mcl-1cKO (n=50), Mcl-1^+/+(n=33), and Mcl-1c/BaxDKO (n=49) MII oocytes were stained with MitoTracker Red. Values represent fold change of average RFUs per oocyte±S.E.M. normalized to average Mcl-1^+/+ value. (e) Chromosomal misalignments in Mcl-1cKO (n=70), Mcl-1^+/+ (n=89) and Mcl-1c/BaxDKO (n=19) oocytes were quantitated (from n=4, n=5 and n=2 animals, respectively). Values represent percentage of oocytes with misaligned or normal chromosomes/total oocyte pool. Mcl-1c/BaxDKO data were all graphed against Mcl-1cKO and Mcl-1^+/+data from Figures 2,4 and 5. (*P<0.05, **P<0.01, ***P<0.001). Genotypes in legend apply to all graphs