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. 2015 Jan 22;6(1):e1605. doi: 10.1038/cddis.2014.549

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International Licence. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons licence, users will need to obtain permission from the licence holder to reproduce the material. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/

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Antioxidant treatment rescued Bmi1^−/− hair cells. (a) In vitro study showed that NAC treatment rescued Bmi1^−/− hair cells from neomycin injury. (b) In vivo study showed that neomycin induced hair cells loss attenuated in Bmi1^−/− cochlea after neomycin treatment. (c and d) Statistical data of survival hair cells after neomycin and NAC treatment. Scale bars: 20 μm. *P<0.05 versus Neo-Bmi1^+/+ group; ^#P<0.05. n=5 for each group