. 2015 Jan 15;6(1):e1600. doi: 10.1038/cddis.2014.565

Table 2. Different functions and related target genes between HIF-1 and HIF-2.

HIF-1α	HIF-2α	Function	Gene	Cell type	References
+	−	Endothelial cell proliferation, migration, and vessel sprouting	CXCR4	Endothelial cell	²²
−	+	Controlling vascular morphogenesis, integrity, and assembly	CXCR4	Endothelial cell	²²
−	+	Regulates embryonic vasculature	Tie2	Embryonic kidney cells	¹
−	+	Increases IL-8 expression	c-Myc, Mxi-1	HMEC-1 cells	²⁴
−	+	A stronger transactivation activity on VEGF promoter	(HIF-2 DNA binding sequences)	Hepa-1,Hep3, Ka13, fetal kidney cell line mouse,MG63 Vhlh-deficient mice	^{2, 13, 25}
+	−	Facilitates cell growth and tumorigenesis	CCNG2,ANGPTL4	SW480, DLD-1 cells	²⁸
−	+	Promotes tumor growth	BNip3 transcriptional regulator	RCC	^{29, 30, 31, 32}
−	+	Transformation of dysplastic cells	Cyclin D1, GLUT-1,	RCC	^{30, 33}
−	+	Increases proliferation	VEGF, TGF-α	Endothelial cells	³⁵
−	+	Retards tumor cell migration	iNOS	Endothelial cells	³⁶
−	+	Angiogenesis	TGF-β1	Prostate tumor	³⁸
−	+	Regulates stem cell	Oct4, CD133	Embryos, glioblastoma	^{39, 40}