Figure 3.

Metabolic and mitochondrial pathways are altered in the liver during ageing of WT and Casp2^−/− mice. Pathway enrichment analysis of liver proteins that are differentially abundant during ageing of (a) WT mice, (b) Casp2^−/− mice and between genotypes of (c) young and (d) aged Casp2^−/− and WT mice. Orange colour represents increased proteins, and blue represents decreased proteins.Vertical lines display cutoff for significance of (−log10(P-value)) with Benjamini's correction. Enrichment of Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway was performed using DAVID Bioinformatics resources 6.7 (http://david.abcc.ncifcrf.gov). Details of individual proteins included in each enriched biochemical pahtway can be found in Supplementary Table S5. See Supplementary Figure S3