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. 2015 Jan 29;6(1):e1626. doi: 10.1038/cddis.2014.586

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International Licence. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons licence, users will need to obtain permission from the licence holder to reproduce the material. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0

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LMP2 knockdown by shRNA reduced activation of astrocytes and microglia after MCAO. Following MCAO, GFAP and OX42 immunoreactivities were evident in the right cortex and striatum in ischemic animals receiving control-ShRNA compared with sham-operated control animals. In contrast, the GFAP and OX42 immunoreactivities were significantly reduced in ischemic animals receiving LMP2-shRNA (*P<0.001, compared with the sham-operated controls; ^#P<0.001 compared with the cont-shRNA group). Scale bars=50 μm. Five rats in each group were used for immunofluorescent assays (n=5)