Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Feb 12;6(2):e1635. doi: 10.1038/cddis.2014.594

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International Licence. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons licence, users will need to obtain permission from the licence holder to reproduce the material. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0

PMC Copyright notice

HDAC7 expression results in the enrichment of apoptotic and immune system programs and p53 activation in SD-1 cells. (a) and (b) Heatmaps showing significantly (adjusted P<0.05) enriched GO biological processes and KEGG pathways among the upregulated genes after HDAC7 expression. (c) RT-qPCR validation for the selected upregulated genes. *P<0.05; **P<0.01. (d) TF-binding sites enriched in the upregulated genes after HDAC7 expression. p53 target genes are shown. (e) Representative western blot of SD-1-1-Tet-On-Tight HDAC7 and Namalwa-1-Tet-On-Tight HDAC7 cells treated, or not, with doxycycline for the indicated times showing p53 phosphorylation and acetylation status