Table 1. Gene array analysis.
| Ratio: (log2)a TAM67+/TAM67− | Gene name | Entrez gene ID | Description | Category |
|---|---|---|---|---|
| Gene expression elevated in TAM67-negative epidermis | ||||
| Cutaneous keratins | ||||
| −4.08 | Krt71 | 56735 | Keratin 71 | |
| −3.64 | Krt25 | 70810 | Keratin 25 | |
| −3.47 | Krt27 | 16675 | Keratin 27 | |
| −3.47 | Krt26 | 320864 | Keratin 26 | |
| −3.04 | Krt15 | 16665 | Keratin 15 | |
| −3.02 | Krt28 | 70843 | Keratin 28 | |
| −2.88 | Krt72 | 105866 | Keratin 72 | |
| −2.41 | Krt77 | 406220 | Keratin 77 | |
| −2.37 | Krt73 | 406220 | Keratin 73 | |
| −2.32 | Krt23 | 94179 | Keratin 23 | |
| −2.13 | Krt78 | 332131 | Keratin 78 | |
| Hair keratins and associated proteins | ||||
| −3.66 | Krt33a | 71888 | Keratin 33a | |
| −3.19 | Krt86 | Keratin 86 | ||
| −2.47 | Krt31 | 16660 | Keratin 31 | |
| −4.43 | Krtap7-1 | 71363 | Keratin associated protein 7-1 | |
| −4.39 | Krtap8-1 | 16703 | Keratin associated protein 8-1 | |
| −3.46 | Krtap3-3 | 66380 | Keratin associated protein 3-3 | |
| −3.27 | Krtap1-5 | 69664 | Keratin associated protein 1-5 | |
| −3.04 | Krtap6-1 | 100040214 | Keratin associated protein 6-1 | |
| −3.03 | Krtap16-8 | 68484 | Keratin associated protein 16-8 | |
| −2.92 | Krtap4-16 | 435285 | Keratin associated protein 4-16 | |
| −2.91 | Krtap4-1 | 665891 | Keratin associated protein 4-1 | |
| −2.77 | Krtap8-2 | 16704 | Keratin associated protein 8-2 | |
| −2.67 | Krtap13-1 | 268905 | Keratin associated protein 13-1 | |
| −2.64 | Krtap6-3 | Keratin associated protein 6-3 | ||
| −2.57 | Krtap4-7 | 76444 | Keratin associated protein 4-7 | |
| −2.23 | Krtap1-4 | 629873 | Keratin associated protein 1-4 | |
| −2.03 | Krtap4-2 | 68673 | Keratin associated protein 4-2 | |
| −1.83 | Krtap3-1 | 69473 | Keratin associated protein 3-1 | |
| −1.83 | Krtap16-7 | 170656 | Keratin associated protein 16-7 | |
| −1.80 | Krtap3-2 | 66380 | Keratin associated protein 3-2 | |
| −1.77 | Krtap1-3 | 435273 | Keratin associated protein 1-3 | |
| −1.70 | Krtap16-5 | 77918 | Keratin associated protein 16-5 | |
| Early envelope | ||||
| −1.8 | Sprr4 | 229562 | Small protein-rich protein 4 | |
| Late envelope | ||||
| −3.97 | Lce1m | 66203 | Late cornified envelope 1M | |
| −3.83 | Lce1d | 69611 | Late cornified envelope 1D | |
| −3.79 | Lce1a2 | 73722 | Late cornified envelope 1A2 | |
| −3.73 | Lce6a | 78382 | Late cornified envelope 6A | |
| −3.56 | Lce1f | 67828 | Late cornified envelope 1F | |
| −3.51 | Lce1e | 68694 | Late cornified envelope 1E | |
| −3.40 | Lce1b | 68720 | Late cornified envelope 1B | |
| −3.37 | Kprp | 433619 | Keratinocyte proline-rich protein | |
| −3.23 | Lce1l | 73730 | Late cornified envelope 1L | |
| −2.79 | Lce1c | 73719 | Late cornified envelope 1C | |
| −2.48 | Lce1a1 | 67127 | Late cornified envelope 1A1 | |
| −2.29 | Lce1h | Late cornified envelope 1H | ||
| −2.16 | Lce1j | Late cornified envelope 1J | ||
| −2.16 | Lce1g | 66195 | Late cornified envelope 1G | |
| −2.67 | Lor | 16939 | Loricrin | |
| Filaggrin-related proteins | ||||
| −5.55 | Flg2 | 229574 | Filaggrin2 | |
| −3.53 | Tchh | 99681 | Trichohyalin | |
| −2.26 | Crnn | 381457 | Cornulin | |
| Proteases and protease inhibitors | ||||
| −3.68 | Tmprss11f | 243083 | Transmembrane protease, serine 11f | |
| −3.02 | Serpina12 | 68054 | Serine (or cysteine) peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12 | |
| Lipoxygenases | ||||
| −3.67 | Alox12e | 11685 | Arachidonate lipoxygenase, epidermal | |
| Gene expression elevated in TAM67-positive epidermis | ||||
| Cutaneous keratins | ||||
| +1.75 | Krt6a | 16687 | Keratin 6a | |
| +1.68 | Krt16 | 16666 | Keratin 16 | |
| +1.60 | Krt17 | 16667 | Keratin 17 | |
| Early envelope | ||||
| +2.40 | Sprr2b | 20756 | Small proline-rich protein 2B | |
| +2.14 | Tgm3 | 21818 | Transglutaminase type III | |
| +2.00 | Sprr2d | 20758 | Small proline-rich protein 2D | |
| +1.62 | Sprr2e | Small proline-rich protein 2E | ||
| Proteases and protease inhibitors | ||||
| +4.19 | Serpinb3a | 20248 | Serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3A | |
| +2.51 | Serpinb3d | 394252 | Serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 3D | |
| +1.80 | Serpinb6c | Serine (or cysteine) peptidase inhibitor, clade B (ovalbumin), member 6C | ||
| +2.07 | Spink12 | 78242 | Serine peptidase inhibitor, Kazal type 12 | |
| +2.04 | Klk13 | 626834 | Kallikrein related-peptidase 13 | |
| +1.89 | Serpinb2 | 18788 | Plasminogen activator inhibitor 2 | |
| +1.84 | Capn2 | 12334 | Calpain 2 | |
| Envelope defense | ||||
| +3.82 | S100a8 | 20201 | S100A8 | |
| +3.72 | Defb3 | 27358 | Defensin beta 3 | |
| +3.19 | S100a9 | 20202 | S100A9 | |
| +2.00 | Defb4 | 56519 | Defensin beta 4 | |
| Chitinase-like proteins | ||||
| +4.18 | Chi3l4 | 104183 | Chitinase-3-like protein 3 | |
| Desmosome | ||||
| +1.99 | Dsc2 | 13506 | Desmocollin 2 | |
| +1.91 | Dsg3 | Desmoglein 3 | ||
Larger negative or positive numbers indicate greater enrichment
a
Negative log2 values indicate relative enrichment in TAM67-negative epidermis and positive numbers indicate relative enrichment in TAM67-positive epidermis