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. 2015 Feb 12;6(2):e1640. doi: 10.1038/cddis.2015.3

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International Licence. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons licence, users will need to obtain permission from the licence holder to reproduce the material. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0

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Pin1 overexpression correlates with the hyperphosphorylation of Rb in human breast cancer. (a) Consecutive breast cancer sections were subjected to immunohistochemistry for Pin1 expression or hyperphosphorylated Rb (pS807/811) levels, and photographed under a light microscope. Micrographs were then analyzed and classified as high or low, depending on intensity of staining and percentage of positive cells. Representative images for each level are shown. (b) Summary of Pin1 expression and hyperphosphorylated Rb (pS807/811; ppRb) levels. Correlation was analyzed by the Spearman rank test (P<0.001)