Skip to main content
. 2015 Feb 12;6(2):e1637. doi: 10.1038/cddis.2015.2

Figure 6.

Figure 6

PAK1/NF-κB/IL-6 signaling involved in sunitinib-induced stem-like phenotype in vivo. (a–c) Subcutaneous tumor images and in vivo subcutaneous tumor growth curves (a) and total tumor weight (b) and overall survival analysis (c) (*P=0.0004) of 4 groups of nude mice xenografted with ACHN cells after sunitinib with or without IPA3 (7.5 μM) or anti-IL-6 treatment for 4 weeks are shown. (d) Representative IHC staining images for p-PAK1, IL-6, CD73 and CD146 expression in xenograft RCC tumor tissues from above-mentioned groups (left). Quantified relative p-PAK1, IL-6, CD73 and CD146 expression levels in the above-mentioned groups (right). (e) Representative microphotographs with p-PAK1, IL-6, CD73 and CD146 expression in RCC tumor tissues of 119 RCC specimens. Scale bars, 50 μm (left). Correlation of expression levels of p-PAK1, IL-6, CD73 and CD146 in RCCs (right)