Table 2. Univariate and multivariate Cox regression analysis for overall survival.

Characteristics	Overall survival
	Univariate		Multivariate
	HR (95% CI)	P-valuea	HR (95% CI)	P-valuea
Age (years): ≥60 versus <60	1.721 (0.918–3.230)	0.091
Gender: female versus male	0.788 (0.428–1.451)	0.788
ECOG PS: ≥1 versus 0	1.960 (1.030–3.730)	0.040	1.583 (0.811–3.088)	0.178
Tumor size (cm): >4 versus ≤4	2.557 (1.374–4.757)	0.003	1.295 (0.633–2.652)	0.479
TNM stage: III+IV versus I+II	6.480 (3.224–13.024)	<0.001	3.989 (1.299–12.253)	0.016
Tumor thrombus: yes versus no	10.717 (3.867–29.706)	<0.001	3.042 (1.047–8.839)	0.041
Fuhrman grade: 3+4 versus 1+2	3.729 (1.931–7.202)	<0.001	1.018 (0.364–2.849)	0.973
Necrosis: present versus absent	1.563 (0.863–2.830)	0.140
p-PAK1: high versus low	3.627 (1.922–6.844)	<0.001	2.245 (1.085–4.645)	0.029

Abbreviations: HR, hazard ratio; 95% CI, 95% confidence interval; ECOG-PS, Eastern Cooperative Oncology Group performance status; p-PAK1, phospho-p21-activated kinase 1

^aP<0.05 is considered statistically significant

^aBold values indicate P<0.05