Table 2. The top 10 downregulated and upregulated genes with a P-value <0.05 and ascribed to ‘apoptosis' are shown.
| Gene's name | Log ratio | Relation to breast cancer |
|---|---|---|
| WISP1* | −2.912 | Induction of WISP1 correlates with invasive breast cancer oncogenesis and reduced type 1 cell-mediated cytotoxic immunity: a retrospective study (Klinke et al.,32) |
| SERPINE1* | −2.295 | Plasma PAI-1 levels in breast cancer-relationship with clinical outcome (Ferroni et al.,33) |
| FST* | −2.073 | FST found upregulated in highly invasive MDS-MB-435 overexpressing alpha4beta6 integrins (Chen34) |
| ADAMTS1* | −2.067 | The ADAMTS1 protease gene is required for mammary tumor growth and metastasis (Ricciardelli et al.,14) |
| NRP1* | −2.033 | Neuropilin-1 is expressed by breast cancer stem-like cells and is linked to NFkB activation and tumor sphere formation (Glinka et al.,35) |
| NTS* | −2.024 | The neurotensin receptor-1 pathway contributes to human ductal breast cancer progression (Dupouy et al.,36) |
| ROR1* | −1.970 | ROR1 is expressed in human breast cancer and associated with enhanced tumor cell growth (Zhang et al.,37) |
| ADAM12* | −1.940 | ADAM12 redistributes and activates MMP-14, resulting in gelatin degradation, reduced apoptosis and increased tumor growth (Albrechtsen et al.,38) |
| DAG1 | −1.696 | |
| ABCG2* | −1.510 | Breast cancer resistance protein |
| IRF8* | 1.616 | Epigenetic inactivation of IRF8 in breast carcinoma (among other carcinoma lines; Lee et al.,39) |
| IFI16* | 1.663 | Differential regulation of estrogen receptor a expression in breast cancer cells by metastasis-associated protein 1 (Kang et al.,40) |
| HIST1H1C | 1.799 | |
| ITGA1 | 1.875 | |
| NPTX1 | 1.890 | |
| CXCR3* | 2.004 | C-X-C ligand 10 and C-X-C receptor 3 status can predict tamoxifen treatment response in breast cancer patients (Hilborn et al.,41) |
| KLF2* | 2.217 | Silencing of KLF2 by the histone methyltransferase EZH2 in human cancer (Taniguchi et al.,42) |
| EYA2 | 2.316 | |
| TRIB2 | 2.414 | |
| TXNIP* | 2.680 | Role of thioredoxin reductase 1 and thioredoxin interacting protein in prognosis of breast cancer (Cadenas et al.,43) |
The asterisk indicates that the gene has been associated with breast cancer in the literature. Column 2 indicates the log ratio (ln2) measured in the Affymetrix screen. Column 3 lists one reference of the link between the indicated gene and breast cancer. NA, not applicable.