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. 2015 Feb 12;6(2):e1641. doi: 10.1038/cddis.2015.4

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International Licence. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons licence, users will need to obtain permission from the licence holder to reproduce the material. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0

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Spectral properties of sunitinib and lysosomal accumulation in endothelial cells. (a) Normalized absorption and emission spectra of sunitinib in 0.1% DMSO in 0.9% NaCl. (b) Colocalization of sunitinib (green) and lysotracker (red) in cultured human umbilical vein endothelial cells (HUVEC). Bar in left panel represents 10 μm. (c) Rapid uptake and lysosomal accumulation of sunitinib in HUVEC. Bar in left panel represents 5 μm