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. 2015 Jun 11;6(6):e1782. doi: 10.1038/cddis.2015.134

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Mcl-1 is a common target of cardiac glycosides. U937 cells were treated for 24 h with the indicated concentrations of (a) the cardenolides ouabain, digitoxin and digoxin or (b) the bufadienolides cinobufagin and proscillaridin A. Apoptosis was quantified by analysis the nuclear morphology. Values are the mean of three independent experiments +/− S.D. The levels of the three major anti-apoptotic Bcl-2 proteins were analyzed in parallel by western blot. One of three independent experiments is shown. Statistical analysis was performed with one-way ANOVA test (post-hoc test: Sidak). Significance is reported as *P<0.01, **P<0.01, ***P<0.001 respect control values