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. 2015 Jun 4;6(6):e1775. doi: 10.1038/cddis.2015.146

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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TRPV4-induced apoptosis in hippocampus. (a) Hoechst staining shows that ICV injection of a TRPV4 agonist GSK1016790A (1 μM/mouse) induced apoptosis in the hippocampal CA1 area. Scale bar=50 μM. (b) The bar graph shows the numbers of Hoechst⁺ cells in the hippocampal CA1 area in the presence of different doses of GSK1016790A. **P<0.01 versus control mice. (c) The dose-dependent curve of GSK1016790A-induced apoptosis in the hippocampal CA1 area