Figure 3.

Involvement of signaling pathways in TRPV4-induced hippocampal apoptosis. Hoechst staining (a) and the bar graph (b) show that GSK1016790A-induced apoptosis in the hippocampal CA1 areas was attenuated by 740 Y-P (a PI3K agonist), SB203580 (a p38MPAK antagonist) or Ac-DEVD-CHO (a caspase-3 antagonist), but was unaffected by SP600125 (a JNK antagonist). **P<0.01 versus control mice, ^##P<0.01 versus vehicle-treated GSK1016790A-injected mice