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. 2015 Jun 11;6(6):e1781. doi: 10.1038/cddis.2015.148

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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VDR is essential for basal expression of ΔNp63α. (a) HaCaT (left panel), HaCaT II-4 (right panel) and (b) neonatal human epidermal keratinocyte cells were transfected with non-silencing control (NSC) or siRNA against VDR. The change in mRNA levels and protein expression of p63 and VDR were measured by qRT-PCR (*P values≤0.05) and immunoblot analyses, respectively. (c) The change in transcript levels of p63 and VDR were measured by qRT-PCR in total RNA extracted from skin of wild-type or VDR knockout (KO) mice. *P values≤0.05