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. 2015 Jun 18;6(6):e1793. doi: 10.1038/cddis.2015.159

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Copyright © 2015 Macmillan Publishers Limited

Cell Death and Disease is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Overview of MBD sequencing results. (a) Chromosomal distribution of methylation peaks in control and Dex-exposed NSCs. (b) Venn diagram depicting the proportions of common and unique methylation peaks (DMRs) in control and Dex-exposed P1 NSCs. (c) The DMRs of control and Dex-exposed NSCs were normalized to refGene. Note that the genome-wide DNA hypomethylation induced by Dex exposure affects CpG islands (CGI) and promoter regions to a similar extent. (d) The DMRs distributed within CGI of refGene show similar distribution in control and Dex-exposed NSCs. (e) The proportion of methylation sites that is consistent across passages (P1 → D3) is higher in Dex exposed than in control NSCs (P<0.05, chi-square test for proportions)