Figure 3.

Photopic flicker ERG response results. (A) Representative flicker waveforms at 10 Hz in response to 2.01 log cd-s/m² stimuli for each of the four genotypes. (B) Flicker amplitudes at 10 Hz across multiple intensities, ranging from −1.59 to 2.01 log cd-s/m². *Significant difference compared to Nrl^−/− mice, as determined by 2-way ANOVA with post hoc multiple comparisons. Nrl^−/−Arr4^−/− was significantly increased compared to Nrl^−/− (**P < 0.01) and Nrl^−/−Arr1^−/−Arr4^−/− was significantly decreased compared to Nrl^−/− (***P < 0.001). (C) Flicker amplitudes with a flash intensity of 2.01 log cd-s/m2 across multiple frequencies, ranging from 0.2 to 20 Hz. All three arrestin knockout genotypes were significantly different from Nrl^−/− mice, with Nrl^−/−Arr4^−/− mice having larger amplitudes compared to Nrl^−/− (***P < 0.001) and Nrl^−/−Arr1^−/− mice and Nrl^−/−Arr1^−/−Arr4^−/− mice having smaller amplitudes than Nrl^−/− mice (***P < 0.001 for both).