Table 3.

Genotype distribution and frequency of alleles in diabetic and control subjects

Polymorphisms	Variant	Diabetic subjects, n (%)	Control subjects, n (%)	OR (95% CI)	P-value
NOS	G/G	92 (46)	149 (71.63)	0.337 (0.223–0.508)	<0.001
	G/C	81 (40.5)	48 (23.08)	2.268 (1.477–3.483)	<0.001
	C/C	27 (13.5)	11 (5.29)	2.795 (1.346–5.801)	0.005
	G/C + C/C	108 (54)	59 (28.37)	2.964 (1.967–4.467)	<0.001
	G allele frequency	265 (66.25)	346 (83.17)	0.397 (0.285–0.552)	<0.001
	C allele frequency	135 (33.75)	70 (16.83)	2.518 (1.810–3.502)	<0.001
VEGF	C/C	118 (59)	164 (78.85)	0.386 (0.249–0.597)	<0.001
	C/T	60 (30)	38 (18.27)	1.917 (1.205–3.048)	0.007
	T/T	22 (11)	6 (2.88)	4.161 (1.650–10.492)	0.001
	C/T + T/T	82 (41)	44 (21.15)	2.590 (1.674–4.005)	<0.001
	C allele frequency	296 (74)	366 (87.98)	0.388 (0.268–0.563)	<0.001
	T allele frequency	104 (26)	50 (12.02)	2.571 (1.775–3.725)	<0.001

Abbreviations: OR, odds ratio; CI, confidence interval; NOS, nitric oxide synthase; VEGF, vascular endothelial growth factor.