Effect estimates, as published and bias-adjusted, based on the median of four prior studies comparing conventional to atypical antipsychotic and risk of mortality in the elderly
1. The estimated proportion of defiers was 10%; the estimated proportion of compliers was 34%. Two of the four studies provided information to estimate the proportion of compliers minus the proportion of defiers assuming the proposed instrument was valid: in one study, this was 14%, and in the other it was 30%.