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. 2015 Jun 17;1(5):503–515. doi: 10.1016/j.jcmgh.2015.06.008

Figure 7.

Figure 7

Anti-sense microRNA (as-miR)-221-5p exacerbates trinitrobenzene sulfonic acid (TNBS)-induced colitis. (A) Timeline of as-miR-221-5p treatment in TNBS-induced colitis. (B) TNBS-induced histologic changes in colons of control or as-miR-221-5p-treated C57BL6/J mice. Scale bar: 100 μm. (C) Histopathology score of as-miR-221-5p treated mice with TNBS-induced colitis. (D) Expression level of miR-221-5p was assessed by real-time polymerase chain reaction (PCR) after intracolonic administration of as-miR-221-5p. *P < .05 compared with controls (n = 8). (E) Expression of tumor necrosis factor-α (TNFα), C-X-C motif chemokine 10 (Cxcl10), and collagen, type II, α 1 (Col2α1) in the colon tissue of as-miR-221-5p or as-miR-control treated TNBS mice colitis models. *P < .05 compared with controls (n = 8).