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. 2015 Jun 17;1(5):503–515. doi: 10.1016/j.jcmgh.2015.06.008

Figure 8.

Figure 8

Anti-sense microRNA (as-miR)-221-5p regulates inflammation in dextran sulfate sodium (DSS)-induced colitis models. (A) Timeline of as-miR-221-5p treatment in 1% DSS-induced colitis. (B) Histologic changes in colons of with controls or as-miR-221-5p-treated C57BL6/J mice in DSS colitis model. Scale bar: 100 μm. (C) Expression level of miR-221-5p after intracolonic administration of as-MiR-221-5p. *P < .05 compared with controls (n = 6). (D) Histopathology sore of as-miR-221-5p-treated mice with DSS-induced colitis. (E) The polymorphonuclear neutrophil infiltration sore of as-miR-221-5p-treated mice with DSS-induced colitis. (F) Expression of TNFα, C-X-C motif chemokine 10 (Cxcl10), and collagen, type II, α 1 (Col2α1) in the colon tissue of as-miR-221-5p or anti-miR-control treated DSS-induced colitis models. *P < .05 compared with controls (n = 6).