Table 2.
Seizure incidence rates (in percent) for popular antidepressants and antipsychotics based in the literature
| Antidepressant | Source | Dose (mg/d) | Seizure rate (%) |
|---|---|---|---|
| Bupropion SR | US Food and Drug Administration12 | 100–300 | 0.1 |
| Bupropion IR | US Food and Drug Administration12 | 300–450 | 0.4 |
| Citalopram | Lundbeck Canada Inc.53 | 0.25 (vs 0.23 placebo) | |
| Duloxetine | Eli Lilly and Company51 | 0.2 | |
| Fluoxetine | Eli Lilly and Company48 | 20–60 | 0.2 |
| Fluvoxamine | Edwards et al52 | <100 | 0.2 |
| Mirtazapine | GenMed PC49 | 0.04 | |
| Paroxetine | GlaxoSmithKline Inc.54 | 0.1 | |
| Sertraline | Pfizer-Roerig47 | 0.0–0.2 | |
| Venlafaxine | Pfizer50 | <150 | 0.3 |
| Venlafaxine XR | Pfizer50 | 0 | |
| Tricyclics | Preskorn & Fast56 | 0.1–0.4 | |
| Antipsychotic | US Food and Drug Administration; Alper et al55 | ||
| Olanzapine | 0.9 | ||
| Quetiapine | 0.8 | ||
| Aripiprazole | 0.4 (vs 0.1 placebo) | ||
| Ziprasidone | 0.4 | ||
| Risperidone | 0.3 |
Note: Dosing information is available for some of the medications.
Abbreviations: IR, immediate release; SR, sustained release; XR, extended release.