Table 4.
Predictive value of CAT, CCQ, COPDSS, and AQ20 scores for composite event, categorized into two categories as indicated
| Variable | B | HR | 95% CI | P-value |
|---|---|---|---|---|
| CAT (<13.5 points and ≥13.5 points; n=497) | ||||
| Age (years) | 0.015 | 1.015 | 0.999–1.031 | 0.070 |
| Smoking status (current vs former smoker RC) | −0.254 | 0.776 | 0.563–1.068 | 0.119 |
| FEV1 (%) | −0.005 | 0.995 | 0.987–1.003 | 0.200 |
| Waist circumference | 0.001 | 1.001 | 0.994–1.008 | 0.722 |
| Number of exacerbations in the previous year | 0.056 | 1.058 | 1.018–1.100 | 0.004 |
| Significant cardiovascular comorbidity | −0.061 | 0.941 | 0.682–1.299 | 0.712 |
| CAT ≥13.5 points | 0.334 | 1.396 | 1.076–1.812 | 0.012 |
| CCQ (<2 points and ≥2 points; n=495) | ||||
| ≥Age (years) | 0.015 | 1.015 | 0.999–1.031 | 0.072 |
| ≥Smoking status (current vs former smoker RC) | −0.232 | 0.793 | 0.574–1.095 | 0.159 |
| FEV1 (%) | −0.005 | 0.995 | 0.987–1.003 | 0.210 |
| Waist circumference | 0.000 | 1.000 | 0.993–1.003 | 0.960 |
| Number of exacerbations in the previous year | 0.055 | 1.056 | 1.015–1.099 | 0.008 |
| Significant cardiovascular comorbidity | −0.031 | 0.970 | 0.702–1.340 | 0.852 |
| CCQ ≥2 points | 0.167 | 1.182 | 0.902–1.549 | 0.226 |
| COPDSS (<9.5 points and ≥9.5 points; n=497) | ||||
| Age (years) | 0.017 | 1.017 | 1.001–1.034 | 0.042 |
| Sex (male vs female RC) | 0.272 | 1.312 | 0.857–2.010 | 0.212 |
| Smoking status (current vs former smoker RC) | −0.245 | 0.782 | 0.569–1.076 | 0.131 |
| FEV1 (%) | −0.008 | 0.992 | 0.984–1.001 | 0.077 |
| Number of exacerbations in the previous year | 0.068 | 1.070 | 1.030–1.113 | 0.001 |
| COPDSS ≥9.5 points | −0.092 | 0.912 | 0.672–1.238 | 0.555 |
| AQ20 (<8 points and ≥8 points; n=497) | ||||
| Age (years) | 0.013 | 1.014 | 0.998–1.029 | 0.090 |
| Smoking status (current vs former smoker RC) | −0.258 | 0.772 | 0.561–1.063 | 0.113 |
| FEV1 (%) | −0.005 | 0.995 | 0.987–1.003 | 0.198 |
| Waist circumference | 0.000 | 1.000 | 0.993–1.007 | 0.952 |
| Number of exacerbations in the previous year | 0.058 | 1.060 | 1.019–1.102 | 0.004 |
| AQ20 ≥8 points | 0.150 | 1.161 | 0.892–1.512 | 0.267 |
Notes: Independent variables: age, sex, smoking status, FEV1 (%), waist circumference, number of exacerbations in the previous year, significant cardiovascular comorbidity, and CAT ≥13.5 points. Dependent variable: combined event.
Abbreviations: AQ20, Airways Questionnaire; B, beta coefficient; CAT, COPD Assessment Test; CCQ, Clinical COPD Questionnaire; CI, confidence interval; COPDSS, COPD Severity Score; FEV1, forced expiratory volume in 1 second; HR, hazard ratio; RC, reference category.