. Author manuscript; available in PMC: 2015 Dec 4.

Published in final edited form as: Lab Invest. 2014 Dec 8;95(2):207–222. doi: 10.1038/labinvest.2014.143

Table 1. Summary of the Clinicopathological Features of Patients and Gene Statuses of Derived Cell Lines¹.

Cell lines	Sex	Age	Stage (TNM)	Tumor Site	K-ras	SMAD4³	TP53
MDA-PATC43	F	71	3.0.0	Pancreas	Cod 12: GGT;CGT	Delete	WT
MDA-PATC50	F	60	3.1.0	Pancreas	Cod 12: GGT;CGT	Delete	C(945,1061)>T
MDA-PATC53²	M	65	X.X.1	Liver	Cod 12: GGT;GAT	WT⁴	WT⁴
MDA-PATC66	F	63	3.1.0	Pancreas	Cod 12: GGT; GAT	Delete	T(909,591)>A

All of these patients had no pre-operative treatment, and tumor tissue was confirmed pancreatic adenocarcinoma.

Tumor from liver metastasis site.

Expression of SMAD4 protein was also demonstrated by immunohistochemistry in both patient specimens and murine xenograft tissue (Figure 3.).

⁴

Wild Type.

Table 1. Summary of the Clinicopathological Features of Patients and Gene Statuses of Derived Cell Lines1.