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. 2015 Dec 4;10(12):e0143208. doi: 10.1371/journal.pone.0143208

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Fig 9 — A. Representative immunofluorescence images of rats treated with no irradiation (Control), whole brain irradiation (WBRT), and hippocampal avoidance brain irradiation (HA). For each rat, a section of brain from the cortex (not spared) and a section from the hippocampus (granule cell layer of the dentate gyrus) is shown. A brain map (top) indicates the locations where the images of the cortex and hippocampus are taken. Scale bar = 250 microns. B. Anti-phospho-Histone H2A.X antibody immunofluorescence signal intensity analysis. The radiation-induced phosphorylation of Histone H2A.X in the hippocampus is significantly decreased when the brain is irradiated with hippocampal avoidance, * P = 0.012 (by student t-test). C. Immunofluorescence images of the cortex and hippocampus of a rat treated with WBRT. Red = NeuN (a neuron-specific marker), Green = phosphorylation of Histone H2A.X. Scale bar = 125 microns.