Table 3. Plasma proteins negatively associated with plasma alpha-1-acid glycoprotein (AGP) in 6–8 year old children in rural Nepal, ordered by P. a .
| Protein name | Gene symbol | n b | % change in AGP (95% CI) c | P d | q e | r f | Accession g |
|---|---|---|---|---|---|---|---|
| Lumican | LUM | 500 | -48.9 (-54.8, -42.2) | 9.1E-27 | 7.1E-25 | -0.56 | 4505047 |
| Cartilage oligomeric matrix protein | COMP | 500 | -36 (-41.4, -30.0) | 5.7E-23 | 3.5E-21 | -0.54 | 40217843 |
| Tetranectin | CLEC3B | 500 | -53 (-60.0, -44.9) | 1.0E-20 | 5.4E-19 | -0.53 | 156627579 |
| Transthyretin | TTR | 500 | -48.8 (-55.7, -40.9) | 4.7E-20 | 2.3E-18 | -0.52 | 4507725 |
| N-acetylmuramoyl-l-alanine amidase | PGLYRP2 | 500 | -48.6 (-55.7, -40.4) | 1.2E-18 | 4.9E-17 | -0.52 | 156616294 |
| Apolipoprotein A-I | APOA1 | 500 | -43.2 (-49.9, -35.5) | 1.9E-18 | 7.6E-17 | -0.52 | 4557321 |
| Serine proteinase inhibitor, clade a (alpha-1 antiproteinase, antitrypsin), member 4 | SERPINA4 | 500 | -46.5 (-53.6, -38.4) | 4.9E-18 | 1.9E-16 | -0.51 | 21361302 |
| Inter-alpha globulin inhibitor h2 polypeptide | ITIH2 | 500 | -53.4 (-61.1, -44.2) | 1.1E-16 | 3.9E-15 | -0.50 | 70778918 |
| Alpha-2-macroglobulin | A2M | 500 | -58.5 (-66.4, -48.7) | 3.1E-16 | 1.0E-14 | -0.50 | 66932947 |
| Afamin | AFM | 500 | -38 (-44.7, -30.4) | 4.1E-16 | 1.3E-14 | -0.50 | 4501987 |
| Attractin isoform 2 | ATRN | 500 | -49.2 (-56.9, -40.2) | 4.3E-16 | 1.3E-14 | -0.50 | 21450863 |
| Fibroblast activation protein, alpha subunit | FAP | 423 | -31.7 (-38.1, -24.7) | 1.5E-14 | 4.6E-13 | -0.51 | 16933540 |
| Interferon-related developmental regulator 2 | IFRD2 | 486 | -29.9 (-36.1, -23.2) | 2.2E-14 | 6.3E-13 | -0.49 | 197333755 |
| Apolipoprotein A-II | APOA2 | 500 | -36.3 (-43.4, -28.5) | 2.7E-14 | 7.7E-13 | -0.49 | 4502149 |
| Alpha 3 type vi collagen isoform 5 | COL6A3 | 472 | -38.9 (-46.2, -30.5) | 4.8E-14 | 1.3E-12 | -0.49 | 55743106 |
| Alpha-2-hs-glycoprotein | AHSG | 500 | -39.3 (-46.9, -30.6) | 2.4E-13 | 6.3E-12 | -0.48 | 156523970 |
| Serpin peptidase inhibitor, clade c, member 1 | SERPINC1 | 500 | -61.6 (-70.6, -49.9) | 1.5E-12 | 3.5E-11 | -0.47 | 4502261 |
| Kelch-like protein 34 | KLHL34 | 403 | -36.7 (-44.2, -28.1) | 1.7E-12 | 4.0E-11 | -0.49 | 23397572 |
| Peptidase inhibitor 16 | PI16 | 500 | -31.0 (-37.8, -23.4) | 2.6E-12 | 5.7E-11 | -0.47 | 70780384 |
| Thrombospondin 4 | THBS4 | 451 | -25.5 (-31.4, -19.1) | 2.7E-12 | 5.8E-11 | -0.47 | 31543806 |
| Gelsolin isoform a | GSN | 493 | -36.9 (-44.6, -28.2) | 3.0E-12 | 6.3E-11 | -0.48 | 4504165 |
| Anthrax toxin receptor 2 isoform 1 | ANTXR2 | 367 | -33.4 (-40.6, -25.3) | 3.3E-12 | 6.9E-11 | -0.53 | 50513243 |
| Retinol-binding protein 4, plasma | RBP4 | 500 | -31.6 (-38.5, -23.8) | 3.7E-12 | 7.4E-11 | -0.47 | 55743122 |
| Cd109 antigen isoform 2 | CD109 | 300 | -34.4 (-41.8, -26.1) | 3.9E-12 | 7.8E-11 | -0.56 | 227430301 |
| Timp metallopeptidase inhibitor 2 | TIMP2 | 368 | -33.5 (-40.8, -25.3) | 4.7E-12 | 9.2E-11 | -0.49 | 4507511 |
| Sparc-like protein 1 | SPARCL1 | 493 | -39.5 (-47.9, -29.7) | 4.0E-11 | 7.5E-10 | -0.46 | 190341024 |
| Cadherin 5, type 2 | CDH5 | 500 | -34.1 (-41.9, -25.1) | 1.1E-10 | 2.0E-09 | -0.46 | 166362713 |
| Olfactomedin related er localized protein isoform 1 | OLFM1 | 465 | -36.8 (-45.1, -27.2) | 1.5E-10 | 2.6E-09 | -0.47 | 17136143 |
| Apolipoprotein M | APOM | 500 | -33.8 (-41.7, -24.8) | 1.9E-10 | 3.4E-09 | -0.46 | 22091452 |
| Anthrax toxin receptor 1 isoform 1 | ANTXR1 | 339 | -28.1 (-35.1, -20.4) | 2.4E-10 | 4.1E-09 | -0.49 | 14149904 |
| Plasma serine protease inhibitor | SERPINA5 | 500 | -31.9 (-39.7, -23.1) | 5.2E-10 | 8.8E-09 | -0.45 | 194018472 |
| Cadherin 13 | CDH13 | 465 | -34.4 (-42.6, -24.9) | 7.6E-10 | 1.3E-08 | -0.46 | 4502719 |
| Tenascin xb isoform 1 | TNXB | 500 | -29.5 (-37.1, -21.1) | 1.2E-09 | 1.9E-08 | -0.45 | 188528648 |
| Dipeptidyl peptidase 4 | DPP4 | 416 | -35.3 (-43.9, -25.4) | 2.0E-09 | 3.1E-08 | -0.43 | 18765694 |
| Cd93 antigen | CD93 | 416 | -28.2 (-35.8, -19.7) | 4.9E-09 | 7.4E-08 | -0.47 | 88758613 |
| Xaa-pro dipeptidase isoform 1 | PEPD | 466 | -31.2 (-39.4, -21.9) | 6.5E-09 | 9.7E-08 | -0.45 | 149589008 |
| Microtubule-actin cross-linking factor 1, isoforms 1/2/3/5 isoform a | MACF1 | 430 | -28.2 (-35.8, -19.6) | 6.6E-09 | 9.7E-08 | -0.47 | 33188445 |
| Procollagen c-endopeptidase enhancer 1 | PCOLCE | 500 | -35.3 (-44.2, -25.0) | 6.7E-09 | 9.8E-08 | -0.44 | 157653329 |
| Prenylcysteine oxidase 1 | PCYOX1 | 493 | -27.1 (-34.5, -18.8) | 7.7E-09 | 1.1E-07 | -0.44 | 166795301 |
| Sulfhydryl oxidase 1 isoform a | QSOX1 | 500 | -49.3 (-59.9, -36.0) | 1.0E-08 | 1.5E-07 | -0.44 | 13325075 |
| Apolipoprotein H | APOH | 500 | -29.6 (-37.7, -20.5) | 1.5E-08 | 2.1E-07 | -0.44 | 153266841 |
| Integrin alpha 2 | ITGA2 | 187 | -33.7 (-42.5, -23.5) | 1.6E-08 | 2.1E-07 | -0.49 | 116295258 |
| Membrane alanine aminopeptidase | ANPEP | 500 | -35.2 (-44.5, -24.3) | 4.0E-08 | 5.3E-07 | -0.44 | 157266300 |
| Inter-alpha (globulin) inhibitor h1 isoform a | ITIH1 | 500 | -41.2 (-51.3, -28.9) | 4.0E-08 | 5.3E-07 | -0.44 | 156119625 |
| Biotinidase | BTD | 500 | -35.5 (-44.9, -24.5) | 4.2E-08 | 5.4E-07 | -0.44 | 4557373 |
| Insulin-like growth factor binding protein, acid labile subunit isoform 2 | IGFALS | 500 | -23.7 (-30.7, -15.9) | 4.3E-08 | 5.4E-07 | -0.44 | 4826772 |
| Phosphatidylinositol-glycan-specific phospholipase d isoform 1 | GPLD1 | 500 | -30.1 (-38.6, -20.5) | 5.0E-08 | 6.3E-07 | -0.44 | 29171717 |
| Basement membrane-specific heparan sulfate proteoglycan core protein | HSPG2 | 493 | -40.2 (-50.3, -28.0) | 5.4E-08 | 6.7E-07 | -0.43 | 126012571 |
| Lymphatic vessel endothelial hyaluronic acid receptor 1 | LYVE1 | 479 | -22.9 (-29.8, -15.2) | 6.8E-08 | 8.3E-07 | -0.45 | 40549451 |
| Butyrylcholinesterase | BCHE | 500 | -31.4 (-40.3, -21.2) | 8.9E-08 | 1.1E-06 | -0.44 | 4557351 |
| Osteomodulin | OMD | 465 | -24.9 (-32.4, -16.5) | 9.0E-08 | 1.1E-06 | -0.47 | 4826876 |
| Plasma kallikrein b1 | KLKB1 | 500 | -36.6 (-46.4, -25.0) | 9.4E-08 | 1.1E-06 | -0.44 | 78191798 |
| Sex hormone-binding globulin isoform 1 | SHBG | 486 | -19.6 (-25.9, -12.6) | 2.3E-07 | 2.6E-06 | -0.43 | 7382460 |
| Multimerin-2 | MMRN2 | 444 | -26.3 (-34.5, -17.2) | 2.7E-07 | 3.1E-06 | -0.45 | 221316695 |
| Mannan-binding lectin serine protease 1 isoform 2 | MASP1 | 486 | -26.6 (-34.8, -17.4) | 2.9E-07 | 3.3E-06 | -0.43 | 21264359 |
| Paraoxonase 1 | PON1 | 500 | -21.1 (-28.0, -13.5) | 3.7E-07 | 4.1E-06 | -0.43 | 19923106 |
| Neural cell adhesion molecule 1 isoform 3 | NCAM1 | 453 | -31.9 (-41.4, -20.8) | 5.4E-07 | 5.8E-06 | -0.45 | 115529478 |
| Collagen, type vi, alpha 1 | COL6A1 | 472 | -24.3 (-32.2, -15.4) | 7.9E-07 | 8.5E-06 | -0.45 | 87196339 |
aPlasma proteins that achieved a Bonferroni corrected significance level (P <0.001/982 = 1.02e-06).
bThe number of child plasma samples of each listed protein (50<n≤500).
cPercent change (%) in plasma AGP per two-fold (100%) increase in relative abundance of protein.
d P value for the hypothesis test of null association between plasma AGP and protein.
eAdjusted P value correcting multiple hypothesis testing (false discovery rate).
fCorrelation between plasma AGP concentration and protein.
gGenInfo Identifier for protein sequence assigned by the National Center for Biotechnology Information.