Table 4. Cellular localizati4on and molecular/biological functions of plasma proteins associated with α-1-acid glycoprotein (AGP) in 6–8 year old children in rural Nepal. a .
| Association | Cellular localization | Molecular/biological function | Protein |
|---|---|---|---|
| Positively associated with AGP (n = 40) | Extracellular (plasma) (n = 23) | Immune system | ORM1/2, APCS, LBP, LRG1 |
| Lipoproteins | SAA1/2/4 | ||
| Complement system | C2/5/9, CFB, CFI, C4BPA, CRP | ||
| Transport/scavenger protein | HP/HPR, CP | ||
| Serine proteases inhibitor | SERPINA3, SERPING1, SERPIND1, ITIH3/4 | ||
| Extracellular (plasma membrane) (n = 1) | Leukocyte-endothelial interaction | ITGAL | |
| Extra- & intra-cellular (n = 2) | Leukocyte trafficking | S100A8/9 | |
| Intracellular (n = 14) | Regulation of cell signaling | MAP3K14, TNIP1 | |
| Transcription and translation regulation, DNA/RNA binding | ELL3, NOM1, TBX22, MED23, NSUN6, ACTR5, MARK3 | ||
| Cell cycle, Cell division, Mitosis | EVI5, ASUN | ||
| Cytoskeleton | DNAAF1, DNAH11 | ||
| ER-Golgi vesicle-mediated transport | COG3 | ||
| Negatively associated with AGP (n = 56) | Extracellular (plasma) (n = 25) | Transport | RBP4, TTR, AFM, AHSG |
| Lipoproteins | APOA1/2, APOH, APOM | ||
| Serine proteinase inhibitor | SERPINA5, SERPINC1, A2M, SERPINA4, ITIH1/ ITIH2 | ||
| Serine type endopeptidase | KLKB1, MASP1 | ||
| Other enzymes | BCHE, PON1, BTD, PCYOX1, GPLD1 | ||
| Inflammatory response | ATRN | ||
| Growth factor/Hormone binding | IGFALS, SHBG | ||
| Peptidoglycan recognition | PGLYRP2 | ||
| Extracellular matrix (n = 11) | Collagen | COL6A1/3 | |
| Non-collagenous glycoprotein | COMP, THBS4, TNXB, SPARCL1, MMRN2 | ||
| Proteoglycan | HSPG2, LUM | ||
| Bone matrix, mineralization | CLEC3B, OMD | ||
| Extracellular (plasma membrane) (n = 20) | Aminoprotease or peptidase | PCOLCE, PEPD, DPP4, FAP, ANPEP | |
| Cell-cell/cell-ECM adhesion | CDH13, CDH5, NCAM1, OLFM1, CD93, ANTRX1, ANTRX2, QSOX1, ITGA2 | ||
| Cytoskeleton modulation | GSN, MACF1 | ||
| Peptidase inhibitor | TIMP2, PI16, CD109 | ||
| Hyaluronan receptor | LYVE1 |
aProteins of unknown function were not presented (KLHL34, IFRD2, and ZZEF1).