Table 1.
Overview of OPTNE50K mouse models for NTG
| Mouse lines | Promotor | Main results | Reference | |||
|---|---|---|---|---|---|---|
| Transgenic mice | ||||||
| Mouse OptnE50K | CAG (CMV immediate enhancer/β-actin) | Progressive retinal degeneration is characterized by loss of RGCs and connecting synapses in the peripheral retina, leading to a thinning of the nerve fiber layer at ONH at normal IOP in 16-month-old mice | [47] | |||
| Human OPTNE50K | c-kit | - | [48] | |||
| BAC-hOPTNE50K | BCA with OPTN endogenous regulatory sequences | More stressed or degenerating optic nerve axons in BAC-hOPTNE50K mice than in 18-month-old control mice at normal IOP | [49] | |||
| Knock-in mice | ||||||
| OptnE50K/E50K | - | The thinning of the RGC fiber layer around ONH from 6 months at normal IOP. At 12 months, the thickness of RGC fiber layer around ONH reduction was 20% compared to WT mice | [16] | |||
| OptnE50K/E50K | - | Aging-related RGC loss and visual dysfunction without elevated IOP | [50] |
BAC=bacterial artificial chromosome, IOP=intraocular pressure, NTG=normal tension glaucoma, ONH=optic nerve head, OPTN=optineurin, RGCs=retinal ganglion cells, WT=wild type