Skip to main content
. 2015 Dec 4;11(12):e1004559. doi: 10.1371/journal.pcbi.1004559

Fig 1. Condition-dependent variants of the NR2 subunits of human NMDA receptors.

Fig 1

(A) The expression profiles of GRIN2A and GRIN2B, the two genes encoding NR2A and NR2B in human cerebellum (CBC). The expression level of GRIN2B (NR2B) declines during prenatal and early childhood, while the expression level of GRIN2A (NR2A) rises during that period. (B) Same as A for RNA-seq Brainspan data [34]. (C) Distribution of correlation values across various gene pairs ad regions in the data of [32]. The curve marked ‘pathways’ corresponds to the all pairs from the brain-related keg pathways. Curves marked with percentages correspond to sets of gene pairs whose sequence overlap is in the designated range, based on biomart overlap measure. Asterisks mark bins of the histogram where the observed number pairs in the 17 pathways is significantly larger (permutation test, p <10–3) from that obtain at random. Dashed line shows the fraction expected at random. (D) Same as C for RNA-seq Brainspan data [34].