Figure 5.

Schematic model of events that occur within CA1 region during acquisition and encoding of memory. We hypothesize that the cellular and neural network changes during Initial Learning lead to the events that occur during Memory Encoding. The temporal time window for the events that occur between the two events may be hours to days, depending on the difficulty of the task being learned and encoded. Importantly the events during the Memory Encoding phase are transient, and will last for few days as memory related cellular changes (e.g., postburst AHP modulation) occur within the neocortical neurons. Once the memory trace has been established in the permanent memory storage sites, the hippocampal circuit returns to the Basal State.