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. Author manuscript; available in PMC: 2015 Dec 4.
Published in final edited form as: J Hypertens. 2015 Mar;33(3):445–453. doi: 10.1097/HJH.0000000000000446

TABLE 3.

Resistance artery smooth muscle function (SMF) assessment in studies included in the meta-analysis

Study, year of publication Vascular region Technique SMF EF
Stimulus OLD vs. YNG Stimulus OLD vs. YNG
Millet et al [30], 2012 supramedial malleolar (skin) laser Doppler SNP iontophoresis ↔ local heating ↔
Donato et al [8], 2011 forearm plethysmography SNP infusion ↔ ACh infusion ↓
Westby et al [24], 2011 forearm plethysmography SNP infusion ↔ ACh infusion ↓
Kirby et al [16], 2010 forearm plethysmography SNP infusion ↔ ACh infusion ↓
Tew et al [19], 2010 forearm (skin) laser Doppler SNP iontophoresis ↓ ACh iontophoresis ↓
Donato et al [6], 2009 forearm plethysmography SNP infusion ↔ ACh infusion ↓
Nicholson et al [31], 2009 forearm plethysmography SNP infusion ↔ N/A N/A
Kirby et al [17], 2009 forearm plethysmography SNP infusion ↓ ACh infusion ↓
Donato et al [32], 2008 forearm plethysmography SNP infusion ↔ ACh infusion ↓
Galetta et al [9], 2006 forearm plethysmography SNP infusion ↔ ACh infusion ↓
Al-Shaer et al [21], 2006 forearm plethysmography SNP infusion ↓ ACh infusion ↓
Newcomer et al [33], 2005 lega ultrasound SNP infusion ↔ ACh infusion ↓
Weverling-Rijnsburger et al [34], 2004 forearm plethysmography SNP infusion ↔ ACh infusion ↔
Ahlers et al [14], 2004 forearm plethysmography SNP infusion ↔ ACh infusion ↓
Smith et al [35], 2003 forearm plethysmography SNP infusion ↔ Bk infusion ↔
Minson et al [18], 2002 forearm (skin) laser Doppler SNP microdialysis ↓ local heating ↓
DeSouza et al [15], 2002 forearm plethysmography SNP infusion ↔ ACh infusion ↓
Wang et al [20], 2002 lower leg (skin) laser Doppler SNP iontophoresis ↔ ACh iontophoresis ↓
Taddei et al [23], 2000 forearm plethysmography SNP infusion ↓ ACh infusion ↓
Gerhard et al [22], 1996 forearm plethysmography SNP infusion ↔ ACh infusion ↓
a

Leg and forearm resistance artery SMF were reported. Leg resistance artery SMF was used in meta-analysis because of lower (as compared with forearm) coefficient of variation

ACh, acetylcholine; Bk, bradykinin; EF, endothelial function; N/A, data not available; OLD, older group; SMF, smooth muscle function; SNP, sodium nitroprusside; YNG, young group; ↔, no significant difference between older and young groups; ↓, significant decrease in older compared with young groups