Table 1.

Clinicopathologic and molecular features of human endometrial carcinoma (EC) subtypes.

	L ow grade Type I ECa	High grade Type I ECa	Type II ECa
Incidence	80–90%	~3%	10–20%
Age	Pre/peri/post-menopausal	Pre/peri/post-menopausal	Post-menopausal
Parity	Nulliparous	Nulliparous	Multiparous
Morphology	Endometrioid	Overlapping Type I & Type II features	Clear/Serous cell
Background	Hyperplastic	Hyperplastic	Atrophic
Invasion	Less invasive	Local invasion	Infiltrative/peritoneal seeding
Behavior	Stable	Agressive	Aggressive
Prognosis	Favorable	Poor (relative to Low grade Type I)	Poor
ER-α expression	Present	Absent	Absent
PR expression	Present	Absent	Absent
TP53 mutation	10–20%	Higher than Low grade	80–90%

^aHorn et al., 2007; Liu 2007; McConechy et al. 2012; Mittal and Barwick, 1988; Ryan et al., 2005; Zannoni et al. 2010.