Table 4.
Incidence of epithelial uterine neoplasms in TBBPA-exposed Wistar Han rats in the two-year NTP bioassay.
| UTERUSa | 0mg/kg | 250mg/kg | 500mg/kg | 1000mg/kg |
|---|---|---|---|---|
| Adenoma (includes multiples) | 3 (6%) | 2 (4%) | 4 (8%) | 6 (12%) |
| Poly-3 testb | P=0.103 | P=0.489N | P=0.437 | P=0.242 |
| Adenocarcinoma (includes multiples) | 4 (8%) | 10 (20%) | 15 (30%) | 16 (32%) |
| Poly-3 test | P=0.002^ | P=0.089 | P=0.002* | P=0.002* |
a
n = 50 animals examined per group
b
The p-value in the control column corresponds to the trend test; p-values in the dose columns correspond to pairwise comparisons with the control group.
N indicates a tumor-rate decrease compared to controls.
^
Statistically significant (p < 0.05) based on poly-3 test for linear trend.
*
Statistically significant (p < 0.05) based on poly-3 test for pairwise comparisons to the controls.