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. Author manuscript; available in PMC: 2016 May 18.
Published in final edited form as: Gene Ther. 2015 Jun 30;22(12):993–999. doi: 10.1038/gt.2015.68

Figure 4. HD-dosing of UTR mRNA Polyplexes.

Figure 4

UTR mRNA (1 µg) was combined with 0.8 nmol of either peptide 1 or 2 to form polyplexes, delivered hydrodynamically to triplicate mice, and assayed for luciferase expression in liver by bioluminescence imaging at 24 hours. Peptide 1 UTR mRNA polyplexes produced 10–15 fold higher luciferase expression compared to pGL3 (1 µg), UTR mRNA alone, or peptide 2 UTR mRNA polyplex. Statistically significant differences relative to UTR mRNA peptide 1 polyplex dose are marked, with ** p ≤ 0.01, *** p ≤ 0.001.