Aged fTreg KO mice are resistant to short-term, but not persistent, HFD-induced weight gain and insulin resistance. (a–e) Aged control and fTreg KO mice were placed on HFD and monitored throughout course of diet for weight (a), fasting glucose levels (b), fasting serum insulin levels (c), performance on GTT (d), and ITT (e). (Control, n=10; fTreg KO, n=11; Mice were aged 27–29 weeks and weight-matched before HFD was introduced.) Data represents mean ± s.e.m. ns – non-significant, *p<0.05, **p<0.01.