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. Author manuscript; available in PMC: 2016 Dec 4.
Published in final edited form as: Glia. 2015 Jun 4;63(11):1982–1996. doi: 10.1002/glia.22868

Figure 3. Elevated levels of encephalitic T-cells within infected brains of animals following acute Treg depletion.

Figure 3

(A) Absolute numbers of CD8+ and CD4+ T-cells were calculated based on flow cytometric analysis of these populations isolated from the brains of MCMV-infected mice with or without DTx treatment during the acute phase of infection (as described in Figure 2). Lymphocyte numbers within the brain were determined at 7, 14, and 30 dpi. Pooled data are presented as mean ± SEM of two experiments using six animals per treatment group/time point. (B) Immunohistochemical staining for CD4+ (blue) and CD8+ (red) T lymphocytes within the ventricles, parenchyma, and meninges of infected animals at 24 dpi with (+DTx) or without (−DTx) DTx treatment. **P ≤ 0.01 vs. −DTx.