Skip to main content
. Author manuscript; available in PMC: 2016 Dec 4.
Published in final edited form as: Glia. 2015 Jun 4;63(11):1982–1996. doi: 10.1002/glia.22868

Figure 9. Long-term neurological sequelae following Treg depletion during acute infection.

Figure 9

(A) Convalescent Foxp3-DTR-GFP transgenic mice with (MCMV +DTx, pink line, n = 13) and without DTx treatment (MCMV, blue line, n = 9), along with uninfected controls (Uninfected, green line, n = 9), were tested for deficiencies in spatial learning and memory using a Barnes Maze at 30 dpi. The time needed to move to the hole with an escape box on each day of testing was recorded as latency to escape (sec). (B) Following 4 d of acquisition using four trials per d (i.e., on d 5), the escape box was covered and the time spent in each quadrant was compared to time spent in the goal zone (90 sec test), which previously contained the escape box. **P ≤ 0.01 vs. MCMV. ††P ≤ 0.01 vs. goal zone of each respective group.