Table 8.

Significant correlation of protein expression by means of Kruskall–Wallis rank test in different glioma subtypes and glioma WHO grades

			Significant correlations Kruskal–Wallis rank test
			Proteins assessed
Subtypes14	Correlated to	WHO grade	EGFR	IDH1R132H	OLIG2	P53	PDGFRA	CD44	MERTK	GFAP	Ki67	MAP2
Classical high EGFR and negative P53 n = 53	Proneural	II–IV	0.000			0.000					0.006
	Mesenchymal	IV (GBM)	0.000			0.000
	Other	III–IV	0.000			0.000
	n = 98	II	0.000			0.001
Proneural high IDH1R132H and/or high OLIG2 and/or high P53 and/or high PDGFRA and/or n = 84	Classical	II–IV	0.000	0.000		0.000		0.000	0.001	0.041	0.003
	Mesenchymal	IV (GBM)	0.003			0.001		0.000	0.022		0.045
	Other	III–IV	0.000	0.008		0.000		0.000	0.008
	n = 117	II	0.007	0.013	0.000	0.000				0.005
Mesenchymal high CD44 and/or high MERTK n = 28	Classical	II–IV				0.000		0.000	0.000		0.008
	Proneural	IV (GBM)	0.003			0.001		0.000	0.000			0.009
	Other	III–IV	0.002			0.000		0.000	0.000			0.021
	n = 160	II						0.001			0.008
Other all low n = 15	Classical	II–IV	0.000	0.001	0.000	0.001		0.031		0.000	0.008
	Proneural	IV (GBM)
	Mesenchymal	III–IV			0.037
	n = 165	II	0.007	0.000	0.001	0.002				0.000

EGFR, Epidermal growth factor receptor; MERTK, proto-oncogene tyrosine-protein kinase MER; IDH1^R132H, isocitrate dehydrogenase 1 mutation R132H; PDGFRA, platelet derived growth factor receptor α.

Italics signify ranges between P = 0.05–0.005.