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Working model for PA puncta in seipin-deleted cells. ER-droplet interface is shown. Left, normally, PA fluxes from generating to metabolizing enzymes. PA flux through the TAG pathway into droplets is not specifically shown. Curvature at the junction is mild or it protected by seipin. Right, in the absence of seipin, some PA is trapped at the ER-drop interface in regions of high curvature, creating punta seen by fluorescence probes
