Table 1.
Characteristics of Study Population by Steatosis Grade
| Variables | Grade 0 N = 24 |
Grade 1 N = 50 |
Grade 2 N = 50 |
Grade 3 N = 50 |
|---|---|---|---|---|
| Age, mean (SD) | 15.1 (2.5) | 14.2 (2.2) | 14.1 (2.2) | 13.2 (2.0) |
| Sex, N (%) | ||||
| Boys | 13 (54) | 35 (70) | 34 (68) | 36 (72) |
| Girls | 11 (46) | 15 (30) | 16 (32) | 14 (28) |
| Weight, mean (SD), Kg | 87.5 (29.8) | 94.5 (21.6) | 94.4 (22.8) | 84.7 (20.6) |
| Height, mean (SD), cm** | 169.2 (12.3) | 164.4 (12.1) | 163.4 (10.3) | 160.6 (10.8) |
| BMI (Kg/m2), mean (SD) | 30.2 (8.3) | 33.8 (6.1) | 35.0 (6.6) | 32.5 (5.5) |
| ALT, mean (SD), U/L** | 22 (24) | 42 (70) | 44 (90) | 77 (67) |
| AST, mean (SD), U/L** | 23 (24) | 33 (46) | 36 (48) | 49 (39) |
| GGT, mean (SD), U/L* | 22 (15) | 29 (24) | 28 (45) | 37 (32) |
| Time between biopsy and MRI, mean (SD), days | 58 (11) | 58 (7) | 63 (7) | 50 (7) |
| Fibrosis, N (%)** | 7 (29) | 21 (42) | 20 (40) | 27 (54) |
| MRI PDFF (SD)** | 2.6 (2.2) | 9.2 (5.8) | 15.1 (6.8) | 26.8 (8.2) |
*
p < 0.05;
**
p < 0.005;
PDFF = proton density fat fraction