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. 2015 Jun 5;44:112–127. doi: 10.1007/s10439-015-1351-2

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© The Author(s) 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Development of eccentric hypertrophy in response to left ventricular overload as predicted by the serial sarcomere deposition model. Long axis view (top), basal slice of short-axis views (middle) and apical slice of short-axis view (bottom). The color code visualizes the relative lengthening of heart muscle cells through serial sarcomere deposition. The increase in left ventricular volume and loss of ellipticity are classical features of left heart failure.