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. 2015 Jun 5;44:112–127. doi: 10.1007/s10439-015-1351-2

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© The Author(s) 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Development of eccentric hypertrophy in response to right ventricular overload as predicted by the serial sarcomere deposition model. Long axis view (top), basal slice of short-axis views (middle) and apical slice of short-axis view (bottom). The color code visualizes the relative lengthening of heart muscle cells through serial sarcomere deposition. Reverse curvature of the septum and D-shape cross section of the left ventricle are classical features of right heart failure.