Table 3.

Effect of genetic reduction of GluN2A expression on NMDAR-mediated synaptic currents.

		P30			P30			P45			P45
		Tau	n	P	N/A Ratio	n	P	Tau	n	P	N/A Ratio	n	P
Pyramidal Neurons
Mecp2 KO-GluN2A Het	Control	93±5	14	^**	1.00±0.06	15	^**	89±6	17	^**	0.99±0.06	16	^**
Mecp2 KO-GluN2A Het	Ifenprodil	67±5	13	^**	0.74±0.06	13	^**	61±5	15	^**	0.64±0.03	15	^**
Mecp2 WT-GluN2A Het	Control	99±7	7	^**	1.06±0.08	7	^**	89±9	12	^**	1.05±0.08	10	^**
Mecp2 WT-GluN2A Het	Ifenprodil	59±7	8	^**	0.69±0.07	8	^**	68±3	13	^**	0.72±0.04	12	^**
Parvalbumin Interneurons
Mecp2 KO-GluN2A Het	Control	85±5	11	^**	0.91±0.08	9	^**	92±10	10	^**	0.88±0.09	10	^**
Mecp2 KO-GluN2A Het	Ifenprodil	55±6	8	^**	0.40±0.08	8	^**	47±5	11	^**	0.48±0.06	11	^**
Mecp2 WT-GluN2A Het	Control	85±8	7	^**	0.91±0.10	6	^**	93±10	7	*	0.90±0.11	7	^**
Mecp2 WT-GluN2A Het	Ifenprodil	48±8	8	^**	0.33±0.09	8	^**	66±5	8	*	0.54±0.06	8	^**

Tau = Time constant of NMDAR-mediated synaptic current decay (ms); N/A Ratio = Ratio of NMDA/AMPAR-mediated synaptic currents; n=number of cells; All values mean±s.e.m.,

^**

P<0.01,

ANOVA