Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Nov 22;2015:730121. doi: 10.1155/2015/730121

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2015 Jing Zhang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

Resveratrol downregulates the expression of CXCR4 in PC12 cells treated with 6-OHDA. Immunofluorescent staining (a–d) and Western blotting (e, f) were used to determine the expression of CXCR4. (a) In normal control group, the intensity of the staining was weak. After being treated with 6-OHDA, the fluorescent intensity was increased (b). In the presence of resveratrol, this increase was effectively decreased (c). Arrows (a, b, and c) indicated the positive fluorescent staining. (d) Quantification of fluorescent intensity of PC12 cells in different group. In Western blotting, the level of CXCR4 protein was significantly increased in cells treated with 6-OHDA and preincubation with resveratrol could decrease the upregulated protein levels of CXCR4 (e and f). Values of fluorescent intensity were presented as means ± SD from five independent experiments. ^∗ p < 0.01 versus control group, ^# p < 0.01 versus 6-OHDA injury group. Scale bars: (a–c) 100 μm.