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. 2015 Nov 22;2016:5810908. doi: 10.1155/2016/5810908

Figure 4.

Figure 4

FGF-9 promotes c-Kit activation and endothelial cell differentiation in post-MI C57BL/6 and db/db mice. Representative images are shown in (a) demonstrating c-Kit+ve cells in red (A, E, I, M, Q, and U), CD31+ve cells in green (B, F, J, N, R, and V), total nuclei in blue (C, G, K, O, S, and W), and merged images (D, H, L, P, T, and X). Enlarged images depicting colocalization of c-Kit+ve and CD31+ve cells are presented in yellow boxes in (a) (D, H, L, P, T, and X). Scale bar = 100 μm (b) Histogram of quantified c-Kit+ve/CD31+ve cells in C57BL/6 and db/db infarcted hearts suggest FGF-9 enhances c-Kit activation and EC differentiation. ∗ p < 0.05 versus MI. EC = endothelial cell.