Table 6.
The guidelines recommend doses of beta-lactam antibiotics for anti-infective therapy in neonates.
| Amoxicillin | Ceftazidime | Cefotaxime | Meropenem | Latamoxef | |
|---|---|---|---|---|---|
| BLUE | PNA <7 day: 30–60 mg/kg Q12h PNA ≥ 7 day: 30–60 mg/kg Q8h |
PNA<7 day: 25 mg/kg Q12h PNA ∼ 7–21 day: 25 mg/kg Q8h PNA ∼21–28 day: 25 mg/kg Q6h |
PNA <7 day: 25–50 mg/kg Q24h PNA ∼ 7–21 day: 25–50 mg/kg Q12h PNA ≥ 21 day: 25–50 mg/kg Q8h |
PNA <7 day: 40 mg/kg Q12h PNA ≥ 7 day: 40 mg/kg Q8h |
/ |
| BNFC | PNA <7 day: 30–50 mg/kg Q12h PNA ≥ 7 day: 30–50 mg/kg Q8h |
PNA<7 day: 25 mg/kg Q12h PNA ∼ 7–21 day: 25 mg/kg Q8h PNA ∼21–28 day: 25 mg/kg Q6h |
PNA <7 day: 25 mg/kg Q24h PNA ∼ 7–21: 25 mg/kg Q12h PNA ∼21–28 day: 25 mg/kg Q8h |
PNA <7 day: 20 mg/kg Q12h PNA ≥ 7 day: 20 mg/kg Q8h |
/ |
| FDAL | 30 mg/kg/day Q12h | PNA <7 day: 50 mg/kg Q12h PNA ∼7–28 day: 50 mg/kg Q8h |
30 mg/kg Q12h | / | 40–80 mg/kg/day Q6–12 ha |
a
The relevant dose was not retrieved and was substituted using the Chinese drug instruction dose. BLUE: The Blue Book; BNFC: British National Formulary for Children; FDAL: Food and Drug Administration Label; PNA: postnatal age.