Analysis of MAPK‐docking motif emergence (based on p‐BLAST searches) paints a dynamic picture of MAPK pathway evolution. The panel was made based on 62 independent MAPK D‐motif occurrences (see
Table EV3). The histogram counts the number of known D‐motifs (blue bars and blue numbers) and those newly identified in our experiments (red bars and red numbers). An approximate timeline is also added to give a realistic scale of the time dimension. The percentage of mammalian motifs found in selected model organisms is also indicated. Among model organisms, mice and zebrafish are relatively similar to human based on their MAPK interactomes. But fruit flies or yeast are rather poor models due to the low number of docking motifs being conserved across species.