Table 1.
Validated sequences grouped by D‐Motif class
| Greater MEF2A class (phosphorylation by p38α) | Greater DCC class (phosphorylation by ERK2) | Greater HePTP class (phosphorylation by ERK2) | ||||
|---|---|---|---|---|---|---|
| MEF2A‐type | MKK6‐type | Misc. | DCC‐type | Far1‐type | Ste7‐like | HePTP‐like |
| AAKG2/PRKAG2 (28–37) | CCNT2 (498–509) | AMPD1 (109–120) | DCC (1,144–1,155) | CBLB (489–500) | RHDF1/iRhom1 (11–24) | ZEP1/HIVEP1 (1,422–1,438) |
| JAZF1 (77–86) | GAB3 (363–374) | AMPD3 (79–90) | CACNA1G (1,030–1,041) | ELMSAN1 (601–612) | RHDF2/iRhom2 (18–31) | |
| INO80a (1,318–1,327) | INO80a (1,316–1,327) | TRERF1 (653–664) | ||||
| MEF2A (268–277) | KSR2 (330–341) | GAB1 (526–536) | ||||
| KLF3 (88–97) | KMT2C/MLL3a (1,195–1,206) | |||||
| KMT2C/MLL3a (1,197–1,206) | ||||||
| RIPK2a (326–335) | ||||||
| TSHZ3a (321–330) | ||||||
| JIP1 class (phosphorylation by JNK1) | APBA2/MINT2 (279–285) | ATF2 (164–170) | ATF7 (162–168) | APC2 (962–968) | BMPR2 (753–759) | DOCK5 (1,762–1,768) |
| DOCK7 (884–890) | DUSP10/MKP5 (18–24) | ELK1 (314–320) | IRS1 (856–862) | JIP3 (203–209) | M3K10/MLK2 (876–882) | |
| MADD (809–815) | MCL1 (136–142) | MYO9B (1,249–1,255) | PDE4B (72–78) | PRGC1/PPARGC1A (253–259) | SAC2/INSPP5 (1,009–1,015) | |
| NFAT4 class (phosphorylation by JNK1) | AKAP6/mAKAP (433–440) | CCSER1 (573–580) | DYH12/DNAH12 (12–19) | FMN1 (672–679) | FHOD3 (506–513) | JUND (46–53) |
| KANK2 (244–251) | M3K10/MEKK1 (1,077–1,084) | MABP1 (1,292–1,299) | NFATC3/NFAT4 (145–152) | RIPK2a (327–334) | TSHZ3a (322–329) | |
The table lists motifs that tested as positive (“hits”) in the dot‐blot arrays and it shows the most commonly used names of proteins (when necessary, two variants), together with the position of the core motif—based on the reference isoform featured in UniProt. Names in bold type denote previously known docking motifs, while the names in normal type indicate novel interactors.
a
Denotes motifs that appear under more than one class as they satisfy multiple consensus sequences.