Table 4.
Secondary End Points | Quartiles of Urinary Potassium Excretion (g/d) | |||
---|---|---|---|---|
Q1 (<1.72) | Q2 (1.72–2.32) | Q3 (2.33–2.90) | Q4 (>2.90) | |
CVD events (n=115)a | 1 (Reference) | 0.82 (0.50 to 1.34) | 0.69 (0.40 to 1.19) | 0.42 (0.22 to 0.81) |
50% decline in eGFR (n=68)a | 1 (Reference) | 0.78 (0.40 to 1.51) | 0.71 (0.35 to 1.43) | 0.24 (0.08 to 0.70) |
Progression to CKD stage 4 (n=32)a | 1 (Reference) | 0.69 (0.25 to 1.92) | 0.50 (0.18 to 1.40) | 0.08 (0.01 to 0.50) |
Annual decline rate in eGFRb | −2.2 (−2.4 to −1.8) | −1.9 (−2.0 to −1.8) | −1.7 (−2.0 to −1.5) | −1.3c (−1.5 to −1.0) |
CVD, cardiovascular disease; Q1, first quartile; Q2, second quartile; Q3, third quartile; Q4, fourth quartile.
Values are adjusted hazard ratios (95% confidence intervals). Hazard ratios are adjusted for the baseline data, including age, sex, body mass index, hemoglobin A1c, total cholesterol, log triglyceride, log HDL-cholesterol, LDL-cholesterol, systolic BP, renin-angiotensin system inhibitor, hypertension, log urinary albumin excretion rate, eGFR, current smoking, and urinary sodium excretion, in the Cox proportional regression analysis.
Data are expressed as ml/min per 1.73 m2 per year (95% confidence intervals).
P<0.01 versus Q1 and Q2.